Tracking Antigen-Specific CD8 T Lymphocytes in the Lungs of Mice Vaccinated with the Mtb72F Polyprotein
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چکیده
منابع مشابه
IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes.
IL-21, a member of the common gamma-chain family of cytokines, has pleiotropic effects on T, B, and NK cells. We found that IL-21 and the prototype common gamma-chain cytokine IL-2 can stimulate proliferation and cytokine secretion by Ag-specific rhesus monkey CD8+ T cells. However, unique among the members of this family of cytokines, we found that IL-21 drives these cells to apoptosis by down...
متن کاملActivated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections.
The poor correlation between cellular immunity to respiratory virus infections and the numbers of memory CD8(+) T cells in the secondary lymphoid organs suggests that there may be additional reservoirs of T cell memory to this class of infection. Here we identify a substantial population of Ag-specific T cells in the lung that persist for several months after recovery from an influenza or Senda...
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1Baylor National Institute of Allergy and Infectious Diseases (NIAID) Cooperative Center for Translational Research on Human Immunology, INSERM U899, Baylor Institute for Immunology Research, Dallas, TX; 2Baylor University, Waco, TX; 3University of Texas Southwestern, Dallas, TX; and 4Department of Microbiology, Emerging Pathogens Institute, and NIAID Center for Investigating Virus Immunity and...
متن کاملBroad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines.
The development of novel human vaccines would be greatly facilitated by the development of in vivo models that permit preclinical analysis of human immune responses. Here, we show that nonobese diabetic severe combined immunodeficiency (NOD/SCID) beta(2) microglobulin(-/-) mice, engrafted with human CD34+ hematopoietic progenitors and further reconstituted with T cells, can mount specific immun...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2005
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.73.9.5809-5816.2005